08.22/2025

Estimating cardiovascular effects of influenza vaccination in older adults: a target trial emulation using proximal causal inference

BackgroundThe substantial burden of cardiovascular diseases highlights the urgent need for cost-effective interventions to mitigate their impact. While existing evidence on the cardioprotective effect of the influenza vaccine comes primarily from populations with cardiovascular comorbidities, these studies remain susceptible to several sources of bias, including immortal time bias and unmeasured confounding....

04.18/2025

Application of a Digital Injury-Surveillance Platform

IntroductionInjuries pose a considerable burden worldwide, accounting for 9.8% of all-cause disability-adjusted life-years globally.1 Reliable surveillance systems play a pivotal role in injury prevention and control. With rapid advances in digital technologies, digital surveillance frameworks have emerged in recent years and been widely applied to infectious diseases2 but less commonly in the context ...

03.26/2025

Association Between Use of Sodium–Glucose Cotransporter 2 Inhibitors and Epilepsy: A Population-Based Study Using Target Trial Emulation

OBJECTIVEPreclinical studies in animals have suggested potential neuroprotective effects of sodium–glucose cotransporter 2 inhibitors (SGLT-2is), but no epidemiological study has investigated the potential effects of SGLT-2is on epilepsy risk. We aimed to assess the association between use of SGLT-2is and epilepsy incidence.RESEARCH DESIGN AND METHODSWe emulated a target trial comparing SGLT-2is and ...